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J Biol Chem 277 : 3079230797

[Diagram suggestion: three-column flowchart showing Phase 1 "GI Adaptation," Phase 2 "Appetite Suppression Plateau," and Phase 3 "Therapeutic Dose," with decision gates between each phase] Phase 1: GI Adaptation (weeks 1-2 at each new dose) The first two weeks after any dose increase are dominated by GI side effects

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Mutations in the GCKR and MBOAT7 genes are also linked to MASLD

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