These enzymes are responsible for the metabolism of both exogenous and endogenous compounds
Furthermore, oridonin increased the expression of the pregnane X receptor, thereby upregulating CYP3A4 and P-glycoproteinkey elements in detoxification and mucosal barrier maintenance, thus offering a dual anti-inflammatory and barrier-protective effect
Current PD therapy is limited exclusively to improving hypokinetic, motor symptoms with dopamine substitutes, such as L -DOPA, and therefore improves the quality of life of patients for several years, but also leads to the development of uncontrolled, involuntary movements, known as dyskinesia [161, 162]
Balakumar 2010
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Melanocortin receptor agonist studied for MC1R/MC4R-mediated anti-inflammatory effects