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The mean (SD) absolute weight loss from the index date to the end of follow-up was 14.6 (9.9) kg in the semaglutide 2.4 mg cohort and 17.2 (11.7) kg in the tirzepatide cohort, which represented a mean (SD) percent weight loss of 14.1% (9.6) and 16.5% (10.8), respectively

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The right choice simply depends on your specific health needs, insurance situation, and what your provider recommends for your unique circumstances

Finally, one can foresee a future where combination therapy becomes common: for example, a patient with diabetes and obesity might be on both a GLP-1 RA and an SGLT2 inhibitor (for complementary weight loss and cardio-renal protection, which is already done)

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All CASSCF calculations used the SVP basis set