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While GLP-1 (glucagonlike peptide 1) agonist drugs such as semaglutide target a single hormone receptor that regulates hunger, GLP-3s target multiple receptors, including GLP-1, the glucose-dependent insulinotropic polypeptide (GIP) and the glucagon receptor

This changed after Dupr joined Roger Unger (figure 15), an American endocrinologist at the University of Texas Southwestern Medical Center in Dallas with a strong interest in glucagon and diabetes

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Therefore, it was decided not to use the SPEAD method