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Acute pancreatitis is a rare but potentially life-threatening adverse effect associated with GLP-1 receptor agonists, including tirzepatide

Loss of skeletal muscle ERR receptors leads to severe exercise intolerance

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Watch for any reaction: redness lasting more than 30 minutes, itching, burning, breakouts in treated areas, or increased skin sensitivity to other products or environmental factors

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I don't think that means we need to throw the baby out with the bathwater