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The strongest human evidence is topical, including the Leyden 2002 photoaging trial and a 2023 IRB-approved 21-woman topical NEEL gel study reporting an average 28% increase in skin collagen density at 3 months

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Most protocols run weekly, with some clinics using twice-weekly or every-other-week schedules depending on the formulation and the patient

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Key Takeaway: The distinction between research-grade and pharmaceutical-grade peptides represents a critical safety consideration

However, Tylenol does carry the risk of liver damage and glutathione depletion, especially if overused or used alongside alcohol