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The Numbers That Matter: In the landmark SURMOUNT-5 trial published in the New England Journal of Medicine in May 2025, participants taking tirzepatide lost an average of 20.2% of their body weight over 72 weeks, compared to 13.7% with semaglutide
However, it can be difficult to maintain these levels, especially as you get older, live under constant stress, or have an ongoing health problem
Allen DW et al
It is important to confirm exact pricing and medication sourcing before enrollment, as compounded versus branded inventory and supplier arrangements differ across regions
It is still important to know that there are no large-scale studies that have proved the safety of GLP-1 medications while breastfeeding
It can also be found in certain foods like meat, poultry, and dairy
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