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First, failure occurring at supraphysiologic exposure levels is a strong indicator of pharmacologic rather than biological failure

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reported that during the meal, GLP-1 exerted simultaneous effects on insulin secretion and endothelial protection, in a manner dependent on the level of glycemia [107]

New England Journal of Medicine (2025) 6

In doing so, it addresses several of the abnormal and disease-causing factors associated with obesity

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