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Instead, treatments are designed to: Address hyperpigmentation and patchy tone Improve texture, clarity and radiance Treat melasma, sun damage and acne marks Support long-term skin function and barrier health For a medically grounded overview of pigmentation and how it is commonly approached in dermatology, you can refer to trusted international resources such as the Cleveland Clinics guide on hyperpigmentation

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The conversion of 4-hydroxyproline to glyoxylate and ultimately to glycine or oxalate is detailed in the following Figure: The final reaction in this five step metabolic pathway involves the amino transferase encoded by the AGXT gene, alanineglyoxylate and serinepyruvate aminotransferase