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Figure 1 ANS and short-term regulation of body weight The main mediators of short-term regulation of body weight through the sensation of satiety are: - Gastric distension (mediated by vagal afferents) (Figure 1)

Significantly more patients who underwent both supervised exercise and pharmacotherapy maintained at least 10% weight loss one year after treatment cessation (45%), compared to those who received only exercise (29%), only liraglutide (16%) or placebo (10%) (67)

doi:10.1007/s00262-019-02478-7

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