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The peptide sequence Gly-His-Lys chelates a single Cu(II) ion through the histidine imidazole nitrogen and the deprotonated amide nitrogens of the backbone
NICE Evidence Reviews Collection
The injectable GHK-Cu works at a different tissue level than the topical application that follows
Optimal skincare routine order Copper peptide serums belong in the treat phase of skincare routines, after cleansing and toning but before heavier moisturizers and oils
PMCID: PMC12195719
Nature Communications (2025) 8
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