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While GLP-1s undeniably lead to significant weight loss in many patients, individual differences in dose, adherence and lifestyles result in variable outcomes.(10) Health care providers emphasize realistic expectations, as some may lose minimal weight while others lose over 20% body weight
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The mechanism of action is the same as GLP-1, including stimulation of insulin secretion, slowing gastric emptying, and reducing postprandial glucagon secretion in a glucose-dependent fashion
Although rare, there are risks with any procedure and all of the above side effects are considered to be normal
doi: 10.1016/j.molmet.2020.101102 23 AstrupACarraroRFinerNHarperAKunesovaMLeanMEJet al
In contrast to GIPRs, GLP-1Rs are not expressed in adipose tissue (170)
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