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Diebold J et al

Take 100mg once or twice daily

Lenzi A, Gandini L, Picardo M, Tramer F, Sandri G, Panfili E

Mendelian randomization evidence indicates that elevated KYN levels have a causal relationship with increased risk of depression, with each standard deviation increase in KYN corresponding to ~ 1.4-fold higher odds of developing depression [50]

Valproate should not be administered to a woman of childbearing potential unless other medications have failed to provide adequate symptom control or are otherwise unacceptable [seeWarnings and Precautions (5.2, 5.3, 5.4), Use in Specific Populations (8.1), andPatient Counseling Information (17)]

This gap highlights the clinical need for targeted nutritional counseling and, when necessary, supplementation