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Hwang YJ et al

Primary intestinal epithelial cells (IECs) were isolated as described earlier (36)

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The delayed onset reflects bioavailability constraints: oral glutathione is extensively degraded by gamma-glutamyl transpeptidase enzymes in the GI tract, and only chronic dosing saturates these enzymes enough to allow intact tripeptide absorption

Class IV: low solubility, low permeability

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