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The STEP program trials with semaglutide (a GLP-1-only agonist) and the SURMOUNT trials with tirzepatide (dual GIP/GLP-1 agonist) represent the strongest weight loss efficacy data in the history of pharmacotherapy for obesity
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It has been suggested that exaggerated the expression of human islet amyloid polypeptide (hIAPP) in T2D is implicated in the pathogenesis of AD
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GLP-2 is a separate receptor (glucagon-like peptide-2 receptor), primarily studied in gastrointestinal research
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