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The systematic review involved 42 multinational randomized controlled trials, including 48,148 adult patients with type 2 diabetes and concomitant CKD
However, changes in body weight, energy intake, and metabolic signaling can indirectly affect menstrual regularity, particularly when weight loss is rapid or substantial
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At the same time, estrogen supplementation and BNDF upregulation promote the expression of other trophic factors such as the nerve growth factor (NGF) and the neuropeptide Y (NPY) (Nakamura and McEwen, 2005
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