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This dual activation slows gastric emptying, increases feelings of fullness, reduces appetite signals, and improves insulin sensitivity
This delay prolongs nutrient absorption and stabilizes post-meal glucose responses, reducing spikes that can contribute to fat accumulation and energy crashes
2 However, it remains evident that different people respond differently to withdrawal with a subset of the population maintaining weight loss even after cessation of therapy.
These medications reduce gastric acid production, which is necessary for releasing dietary vitamin B12 from food proteins and for maintaining the stability of the B12-intrinsic factor complex
Oktay et al., 2024)
Found in both free and bound forms in central and peripheral tissues
