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It is a key regulatory enzyme and signaling factor for two major incretin hormones: Glucagon-like peptide-1/2 (GLP-1/2) and glucose-dependent insulinotropic polypeptide (GIP) (37, 38)

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Subsequently, activation of adenosine monophosphate (AMP) deaminase occurs, with AMP generated from fructose metabolism entering the purine catabolic pathway, ultimately resulting in the production of uric acid

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