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The mechanism underlying L-Carnitine's anti-obesity effects involves multiple pathways: facilitating long-chain fatty acid entry into mitochondria for oxidation, preventing accumulation of toxic lipid intermediates that impair insulin signaling, enhancing mitochondrial bioenergetics to support greater metabolic capacity, and modulating inflammatory pathways that contribute to metabolic dysfunction
ICH Q2(R2) describes analytical-procedure performance characteristics such as specificity or selectivity, accuracy, precision, detection limit, quantitation limit, linearity, range, and robustness, as applicable to the intended use of the procedure
doi: 10.1002/advs.202412488 468 YousfiH.CassagneC.RanqueS.RolainJ
Besides, ACSL4 sensitizes tumor cells to ferroptosis through increasing the proportion of AA-containing PE species in the cellular membrane [12]
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