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When the chi square test and I 2 statistic results had a considerable issue, then the need for further discussion and conclusion for the heterogeneity was indicated

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PT-141, measured in a single radioligand displacement series against I-NDP-alpha-MSH on membranes from BHK570 cells stably expressing each human subtype, returned Ki 0.25 nM at MC4R, 6.4 nM at MC1R, 17 nM at MC5R and 53 nM at MC3R, roughly 26-fold, 68-fold and 210-fold preference for MC4R over MC1R, MC5R and MC3R respectively

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