The supplement guides are equally applicable to researchers using either cagrilintide or retatrutide
Studies including LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide) have demonstrated reduced cardiovascular events in patients with type 2 diabetes
doi:10.1155/2017/1617458 21
Sophia Newman is the Medical Writer and Speechwriter in the ACS Division of Integrated Communications in Chicago, IL.
These shifts correlated with improvements in metabolic parameters, notably, reduced body weight and improved dyslipidemia (lowered LDL-C and total cholesterol), suggesting that modulation of the gut microbiota is one mechanism by which GLP-1 RAs confer metabolic benefits and lipid-lowering effect ( Bacillota and Bacteroidota alters the pool of intestinal metabolites, in particular by increasing taurocholic acid, which in turn stimulates the release of GLP-1 from L cells, improving glucose tolerance ( Bacteroides , members of the family Lachnospiraceae , and the beneficial genus Bifidobacterium , which was linked to lowered intestinal inflammation and improved glycemic control ( Romboutsia, Ruminiclostridium , and Erysipelotrichaceae ) and enriching lean mass-related genera (e.g., Prevotella ), with an increase in the Bacteroidota - Bacillota ratio and a clear correlation between microbial changes and metabolic parameters
