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Future multicenter double-blind, randomized, placebo-controlled trials in a large and homogeneous sample of patients should focus on higher doses and more prolonged treatment
The efficacy and safety appear to be equivalent between the two methods, even though the interpretation is limited by the small numbers and heterogeneity of selected trials
Significant between-study heterogeneity ( I 2 = 709 %, P = 0002) was reduced by subgrouping by study location, treatment duration and type of control (Table 2)
Key Takeaways Tesamorelin has FDA approval backed by two Phase 3 RCTs showing roughly 15 to 18 percent visceral fat reduction at 26 weeks in HIV-lipodystrophy patients (Falutz et al., 2007, 2010)
About this article Cite this article Handelsman, Y., Muskiet, M.H.A
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