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Alternative evidence-based interventions, including structured lifestyle programmes, psychological support, other pharmacological options, and bariatric surgery (for those meeting criteria), may be more readily accessible and should be considered as part of an individualised treatment plan

Because guidance and enforcement priorities may continue evolving, clinics should regularly monitor FDA communications and consult qualified legal, regulatory, and healthcare professionals when evaluating their GLP-1 programs

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GLP-1RAs have emerged as a promising treatment, offering weight reduction, immune modulation, and glycemic control

doi: 10.1194/jlr.r700019-jlr200 74 LikerB.VranecN.GrbeaD.Baar-HuskiL.MatiI.KneeviM.et al

It involves the direct action of the GLP-1 agonist component on the hearts pacemaker cells, combined with the chronotropic (heart rate-increasing) effects of the glucagon agonist component