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Ferrari R, Merli E, Cicchitelli G et al
This would be in line with preclinical observations that incretin receptor expression is down-regulated by exposure to high glucose, and improves once normoglycaemia is restored (48), and that dys-regulation of glycaemic control in otherwise healthy humans leads to impaired incretin actions (49)
The cell line was further stably transfected with receptor modifying protein 3 (RAMP3) thus generating the human amylin 3 (a) receptor (hAMY 3(a) R)
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Although several studies have investigated GLP-1RAs across mood and anxiety disorders, evidence appears mixed, as beneficial, harmful and null effects have all been reported for depressive symptoms and suicidality
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