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L., and Fariello, R

Changes in organismal nutritional state, such as those induced by fasting or starvation ( FGF21 locus via well-characterized nutritional and metabolite-responsive transcription factors, including fatty acid-responsive nuclear hormone receptors peroxisome proliferator-actived receptor- (PPAR) and PPAR ( FGF21 appears to be mainly synthesized in the liver ( In mice, -Klotho is primarily expressed across metabolic tissues including liver, pancreas, and adipose tissue ( FGFR2c and KLB (the gene encoding -Klotho) are induced upon exposure to FGF21 or an FGF21 analog, consistent with enhanced sensitivity to FGF21s metabolic effects ( In humans, FGFR1c is also the predominantly expressed receptor in adipose tissue, with mRNA levels up to two orders of magnitude higher than for FGFR2c or FGFR3c ( FGF21, FGFR1c , FGFR2c , and FGFR3c are also expressed in skeletal muscle ( FGFR2c and, to a lesser extent, FGFR3c are expressed basally in liver ( FGFR2c is more highly expressed in NAFLD relative to healthy liver ( FGF21 , KLB , FGFR1c , and FGFR3c in the liver, although FGFR2c remains the most highly expressed of FGF21s receptors in the liver

2010 Nov 23

This better roads and crew analogy helps explain why tissues may repair more efficiently under the peptides influence

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