Activation of PKA facilitates membrane depolarization, which consequently opens voltagegated Ca2+ channels, allowing an influx of Ca2+ ions
Hilliou F, Chertemps T, Mabche M, Le Goff G
It is initiated by hypoxic stimulation of peripheral arterial chemoreceptors (carotid and aortic bodies) and central integration of chemosensory inputs in brain stem via medullary respiratory center [47]
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IGF1R autophosphorylation also recruits Shc, which leads to Grb2/SOS/Ras activation and downstream ERK1/2 phosphorylation
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