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Pharmacological inhibition or genetic deletion of TMPRSS2 restores ghrelin signalingdependent GLP-1 secretion and GLP-1s anti-diabetic effects on nutritional glucose homeostasis

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Increasing evidence indicates that high mobility group box 1 (HMGB1), a nuclear protein released from dendritic cells, macrophages, and necrotic cells during inflammation, plays an important pathological role in DKD by activating TLR2 and TLR4 signaling (195)

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