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Neurology 43, 14671472

NAD(H) in mitochondrial energy transduction

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BPC-157 (Body Protection Compound-157) is a stable synthetic pentadecapeptide derived from human gastric juice protein, extensively investigated for its cytoprotective, organoprotective, and vascular-modulating properties in preclinical models

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This GHR upregulation sensitises local cells to circulating GH, potentiating GH-induced JAK2/STAT signalling and stimulating collagen matrix synthesis, IGF-1 production, and fibroblast proliferation providing a mechanism through which BPC-157 engages the GH/IGF-1 axis at the tissue level without altering systemic GH secretion