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Studies demonstrate that the cAMP pathway (GHRH) and calcium/PKC pathway (GHSR) converge synergistically on GH exocytosis the cAMP-mediated vesicle priming is amplified by calcium-triggered membrane fusion

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GHRP-6 demonstrates notable appetite-stimulating effects attributed to GHSR activation in the hypothalamic feeding centers, including neuropeptide Y (NPY) and agouti-related peptide (AgRP) neurons

Gastroenterology 151(1):5169 Chey WD, Leontiadis GI, Howden CW, Moss SF (2017) ACG clinical guideline: treatment of Helicobacter pylori infection

Both the / hydrolase and -propeller domains participate in inhibitor binding