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We report that SAM is central to the improved reprogramming efficiency imparted by vitamin B 12

However, other processes such as immune response, synaptic transmission and endosomal-lysosomal dysfunction were not highlighted which may be due to the smaller sample size in our dataset

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Whey protein supplementation was used as monotherapy in few of the patients who showed improvement

CPT-1 activity was assayed in the supernatant spectrophotometrically by following the release of CoA-SH from palmitoyl-CoA using DTNB (34)

All samples were prepared at the research laboratory of pharmaceutics department, faculty of pharmacy, Minia University