CNS disorders with widespread iron accumulation in areas, including the basal ganglia, might not fully benefit if the drug mainly targets certain areas
Lastly, a series of sensitivity analyses were conducted to corroborate the base-case analysis results and examine the validity of our findings
chronic liver disease and hepatitis may present with elevated levels Renal impairment : Reduced clearance can contribute to accumulation, though this is rarely clinically significant Solid tumours : Certain malignancies, particularly hepatocellular carcinoma and metastatic disease, may elevate B12 levels [3] Evidence suggests that unexplained markedly elevated B12 levels without supplementation may sometimes be associated with underlying disease
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Nephrol Dial Transplant 2014;29:698705.ArticlePubMed 88