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PMID: 41898733

In addition to the actions of vasopressin and aldosterone in the CNT and collecting duct to regulate water, Na + , and K + balance, this region of the nephron also responds to numerous additional hormonal, chemical, and physical inputs

To this end, we have found that IGF-1 signaling is required for PTH to stimulate RANKL (Wang et al., 2007) and ephrin B2/EphB4 (Wang et al., 2010), see Matsuo and Otaki, 2012 for a review of Ephrins), molecules that potentially affect PTH stimulation of osteoclastogenesis as well as osteoblast proliferation and differentiation

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Lack of sleep is a major contributor to health problems across the board