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Di Lorenzo A, Bolli E, Ruiu R, Ferrauto G, Di Gregorio E, Avalle L, Savino A, Poggio P, Merighi IF, Riccardo F, et al
Samuels ER, Szabadi E
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Muscle atrophy and sports medicine research&Wound healing and tissue engineering Indications: muscular dystrophy, AIDS related muscle consumption, muscle atrophy caused by long-term bed rest.Experimental Design:Animal model: Rats were subcutaneously injected with 0.1-0.3 mg/kg IGF-1 LR3, three times a week for 12 weeks, and the results showed a 15-20% increase in muscle strength.Cell experiment: In the myotube culture system, IGF 1 LR3 1mg can induce upregulation of myosin heavy chain (MyHC) expression and promote muscle fiber type transformation
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