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Phosphorylation at S3 inhibits NLRP3 activation, whereas phosphorylation at S194, mediated by JUN N-terminal kinase 1 (JNK1), promotes it

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Nature 583 , 459468 (2020)

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But thats just the beginning

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If you're sitting at your desk all day with no movement, there's very limited demand for energy and very limited fatty acid oxidation happening

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KDM1A, Lysine Specific Demethylase 1

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The next chapter is no longer about hype

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