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Discontinuation rates range from 37% to 81% within the first year, driven by cost, side effects, and access barriers, with weight regain thereafter mediated through hormonal dysregulation, CNS maladaptation to reduced GLP-1 signaling, and -cell dysfunction
Patients who combine Wegovy with mindful eating, portion control, and physical activity tend to achieve more sustainable results, improve overall metabolic health, and maintain their weight loss long-term
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[1] [2] Crucially, this effect is glucose-dependent, meaning insulin release only occurs when blood glucose levels are elevated, which significantly reduces the risk of hypoglycaemia compared to sulfonylureas or insulin therapy, though this risk remains if Ozempic is combined with these medications
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