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MAPK/ERK drives proliferation
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Clinical manifestations range from asymptomatic elevations in serum transaminases to more severe conditions, including cholestatic jaundice, peliosis hepatis, hepatic adenomas, and, in rare cases, hepatocellular carcinoma (75)
Kirk JE (1974)
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To counteract this and make the drug effective for a longer time, inhibitor molecules like that in PDB entry 3gss can be administered along with the drug to inhibit the action of the enzymes
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