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The insoluble fiber in apple skins helps with digestion and can ease constipation, a common side effect of GLP-1 medications

It also helps in reversing the imbalance of matrix metalloproteinases (MMP-9) and their inhibitors (TIMP-1), and in preventing epithelial-mesenchymal transition (EMT) through the modulation of Nrf2, NF-B, and TGF-1/Smad2/3 signaling pathways 6

Sometimes that is different from what you initially wanted, and that is actually a sign the process is working as it should

For instance, N-acetylcysteine (NAC) supplementation significantly reduced the incidence of AKI and overall mortality after cardiac surgery (Magner et al., 2022)