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Native IGF-1's extremely short free half-life of 12-15 minutes is primarily determined by rapid IGFBP capture (which removes it from the free pool), renal filtration of the small 7.6 kDa protein, and IGF-1R-mediated endocytosis and lysosomal degradation

Peaks all-in price runs about $165 a month on the six-month plan with no separate medication bill, while Ro charges a $145 monthly membership plus medication (around $199 for Wegovy pen, or $345-plus total)