Retatrutide is an investigational triple GLP-1, GIP, and glucagon receptor agonist with no current MHRA or EMA marketing authorisation
However, they require clinical assessment to exclude serious pathology
Donald Vollmer Body Works Franklin & Nolensville, TN A 2025 review published in PubMed found that while GLP-1 receptor agonists are effective in reducing fat mass, up to 40% of total weight lost can come from fat-free mass
Differences between semaglutide vs tirzepatide Now that you understand how these GLP-1 agonists work, lets discuss the primary differences between them: Weight loss mechanism Semaglutide and tirzepatide both increase insulin levels, help patients manage blood sugar fluctuations, and encourage weight loss
Back Montesano, R, Schekman, R, Rothman, J, Perrelet, A (7 Jan 2020) 'In Memoriam: Leilo Orci, 1937-2019', Proceedings of the National Academy of Sciences , 117/1, 15-17
One of my patients (let's call her Sarah) came to me feeling hesitant about starting Ozempic