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Neuroendocrine Effects Graf and Kastin (1984) reviewed the multiple physiological effects of DSIP beyond sleep, including its interactions with the HPA axis, pain modulation, and thermoregulation

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Oral supplements face minimal pre-market review

Female participants gained less lean body mass than males

Examples include: ( Glycyrrhiza glabra , Licorice) and derivatives (Glycyrrhizic Acid, Glycyrrhetinic Acid, Licochalcone): Known for their anti-inflammatory properties but may increase cortisol levels and worsen eczema symptoms in some cases

In the United States, it is not approved by the FDA for medical use and is typically available only for research purposes