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Population PK analyses including data from this single-dose study and predicting PK parameters after repeated subcutaneous administration of Lanadelumab 300 mg every two weeks showed that geometric mean ratios (90% CIs) were 1.001 (0.9481.056) for AUC over the dosing interval at steady state and 1.029 (0.9811.081) for C max at steady state

doi: 10.1016/j.cell.2015.05.044 10 KrauthammerMKongYBacchiocchiAEvansPPomputtapongNWuCet al

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11 Furthermore, patients typically prefer once-daily oral treatment vs once-weekly injectables, regardless of the frequency of administration