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Other GLP-1 medications are FDA-approved to treat obesity
J Cell Biol 194(1):715 Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rdmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Frster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, ODonnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
10.1111/cpr.13603 190 ZhangP.CuiY.WangY
Splitting each weekly dose into Monday/Thursday injections reduces peak concentration by ~20%, which may explain reports of reduced nausea in sensitive individuals
Patients who want to protect lean mass during medical weight loss should not rely on cardio alone
Another major advantage of semaglutide is its dosing schedule
