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Most side effects are gastrointestinal, tend to be mild to moderate, and improve over time
Am J Gastroenterol 2024;119:2241-2250
According to the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), gastrointestinal disturbances occur in a significant proportion of patients, with nausea affecting up to 20% of users
The financial loss is real but less costly than running an entire protocol on degraded compound
Continuous GLP-1RA Use Reduces MACE Risk Incident use of GLP-1RAs was associated with a lower risk of MACE compared to incident use of sulfonylureas
Severe, unrelenting pain or burning : particularly if associated with neurological symptoms such as weakness, numbness, or loss of function
