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GPX3 can suppress the expression of HIF-1 by regulating ROS, affecting tumor cell energy metabolism, and inhibiting the growth of melanoma cells (51)

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This regulatory status establishes these peptides strictly as research-use-only materials appropriate exclusively for laboratory investigation in qualified research settings rather than any form of clinical, therapeutic, or diagnostic application

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Challenges include gastrointestinal side effects, nutritional deficiencies due to calorie reduction, muscle and bone loss, low long-term adherence with subsequent weight regain, and high costs, resulting in low cost-effectiveness