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Fill half your plate with non-starchy vegetables at lunch and dinner, and pair fruit with protein or fat to enhance GLP-1 response

10.1038/s41386-019-0380-1 Neuropsychopharmacology 59 IadarolaN

In this post, I take a deep dive into EVOKE and EVOKE+, examining trial design, endpoints, effect sizes, and interpretability

Plan an appointment in the coming weeks: Hair loss persisting for more than 6 months without slowing, a clear pattern emerging (frontal recession, crown thinning), or no regrowth after 12 months despite stable weight

In addition, tirzepatide shows signaling bias at the GLP-1 receptor, preferentially activating cAMP generation while weakly recruiting -arrestin, thereby reducing receptor internalization and desensitization

Since Ozempic slows down digestion, certain dietary modifications may make a difference [9] : Avoid high-fat and greasy foods Choose lower-fiber options initially Limit carbonated beverages Reduce spicy food intake Minimize alcohol consumption Split meals into smaller portions Eating smaller amounts more frequently throughout the day helps prevent overwhelming the digestive system [10]