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Dose adjustments can be made after 4-6 weeks based on rate of progress and tolerance
This can lead to the development of specific antibodies that neutralize the drug or cause allergic reactions, potentially resulting in serious complications for patients
Science 312, 13891392
A 2018 study published in Biochemical Pharmacology showed that inhibiting NNMT with 5-Amino-1MQ led to a reduction in fat mass in mice on high-fat diets
Precision delivery Reaches past the stomach
This work now shows a direct line from biochemical and biophysical understanding of protein interactions to an inhibitor, says Kritzer, who was not involved in the research
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