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As a single-center retrospective analysis, it may be subject to selection bias, and conclusions should be validated in large-scale multicenter prospective studies

As de novo synthesis of ceramide is located in the ER, which is absent in erythrocytes, it is thus assumed that erythrocytic ceramide should directly originate from the hydrolysis of sphingomyelin

Injectable delivery produces measurable plasma levels and allows the peptide to reach tissues that topical application cannot including deeper wound beds, joint spaces in preclinical models, and scalp follicles below the penetration limit of topical creams

2022 May 17;3(5):100633

Initially prescribed for the treatment of type 2 diabetes, their weight-loss potential became a notable side effect