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The outcomes of interest were weight change from baseline (CFB, %) at 52 weeks and proportion of participants losing 5% baseline fasting body weight at 12 weeks at full therapeutic dose (ie, as per the stopping rule for certain weight loss drugs, such as orlistat and liraglutide, when participants fail to achieve 5% baseline fasting body weight at 12 weeks at full therapeutic dose)
2022 Oct 1;150(4 Suppl ):41S-48S
Clinical trials show Semaglutide leads to about 15 weight loss, while Tirzepatide can achieve up to 22.5
KaratasHErdenerSEGursoy-OzdemirYLuleSEren-KoakESenZDet al
Furthermore, as HCPs lack prior experience with muscle-preserving therapies, innovators will need to provide practical education on when and how to use such therapies, likely alongside other AOMs, including diagnostic approaches to identify eligible patient segments in routine practice
doi: 10.3390/biom12081055 162 AnsariniyaHYavariAJavaheriAZareF
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