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(Updated 2025)

Clinical trials have consistently demonstrated the efficacy of semaglutide in promoting weight loss, making it a promising tool for obesity management

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In the present study, we found that cardiac mitophagy dysfunction induced by pressure overload can activate NLRP3 inflammasome, and lead to cardiac hypertrophy, and improving mitophagy by semaglutide could suppress the activation of NLRP3 inflammasome to alleviate cardiac hypertrophy