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Abbreviations and Acronyms CD163 = cluster of differentiation 163 molecule GLP = glucagon-like peptide LDL = low-density lipoprotein MMP = matrix metalloproteinase NASH = nonalcoholic steatohepatitis TIMP = tissue inhibitor of metalloproteinases TNF = tumor necrosis factor Acknowledgments The authors thank Lene Takla, Nikolaj Hansen, Mathilde Bonde, Louise Justesen, Malene Pedersen, Caroline Kvist, and Steen Kryger (Novo Nordisk A/S, Global Research, Denmark) for expert technical assistance with conducting the animal studies, and Christina Rye Underwood for assistance with protein assays

To our knowledge, the strategy of selective prevention of cytotoxicity of cardiac vascular cells following MI and/or IRI to affect whole-organ cardioprotection has never been directly studied

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The product itself does not automatically require medical authorization

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Retatrutide Titration Retatrutide Titration Schedule: Phase 2 Standard and Slow Protocol The retatrutide titration schedule from the Phase 2 trial escalates from 2mg to 4mg to 8mg to 12mg, every 4 weeks (Jastreboff et al., NEJM 2023)